Pathogenesis of Pulmonary Fibrosis and New Approaches to the Therapy
Автор:Evgenii Skurikhin,Olga Pershina and Alexander Dygai Год: 2013 Издание:LAP Lambert Academic Publishing Страниц: 68 ISBN: 9783659308536 The model of irreversible bleomycin-induced pulmonary fibrosis shows that simultaneously with inflammatory cells in interstitial lung tissue of mice C57BL/6 cells with the phenotype Lin–, Sca-1+, c-Kit+, CD34– (HSCs) and hematopoietic progenitor cells (Lin–, Sca-1+, c-Kit+) are identified. During the phase of inflammation, HSCs of bleomycin lungs are characterized with high mitotic activity and the ability to differentiate into myeloid cell. Interstitial infiltration of alveolar ducts and alveoli by immature hematopoietic cells is accompanied by an increase in the level of multipotent progenitor cells in bone marrow and blood. Two subpopulations of mesenchymal stem cells (MSCs): 1 - (CD45-, CD73+, CD90+, CD44+, CD106+) and 2 - (CD45-, CD73+, CD90+, CD31-, CD34-) are defined in the parenchyma of bleomycin lungs upon the collagen deposition and fibroblast progenitor cells admission. MSCs are characterized by high mitotic activity and differentiation in the direction of fibroblast cells,...
