Фармакология, рецептура

Список источников >Нехудожественная литература >Медицинская литература >Фармакология. Рецептура. Токсикология >Фармакология, рецептура >

Mucoadhesive Bilayer Lidocaine Buccal Tablet to Treat Gum Diseases

Автор: Nahid Sharmin and Reza-ul Jalil
Год: 2011
Издание: LAP Lambert Academic Publishing
Страниц: 164
ISBN: 9783846553978
The focus of the pharmaceutical research is being steadily shifted from the development of new chemical entities to novel drug delivery systems of existing drug molecules to maximize their effectiveness in terms of therapeutic action and patent protection. This is made possible by the discovery of various compatible polymers (e.g. Carbopol polymers). Local delivery of the anesthetic agent(e.g.Lidocaine)leads to higher concentration of the drug at the intended site of action using a lower dose with an associated reduction in side effects relative to systemic administration.One of the most critical factors in enhancing the efficacy of a topical anesthetic is maintaining prolonged intraoral mucosal contact. Most topical agents come in gel form, which is difficult to localize to a particular site and easily diluted by saliva.To overcome these problems, bilayer buccal tablets were prepared with carbopol polymer.They seem to solve all these problems associated with the treatment of...
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