Immunoregulatory Proteases in Systemic Lupus Erythematosus
Автор:Khader Valli Rupanagudi Год: 2015 Издание:Scholars' Press Страниц: 136 ISBN: 9783639761269 Systemic lupus erythematosus (SLE) is a chronic autoimmune disease leading to in?ammatory tissue damage in multiple organs (e.g., lupus nephritis). Current treatments including steroids, antimalarials, and immunosuppressive drugs have signi?cant side effects. There is an unmet medical need for new drugs with less side effects. We evaluated the role of two proteases, namely activated protein C (aPC) and cathepsin S (Cat S), in the pathogenesis of SLE in MRL-Fas(lpr) mice.
