Controlled Release Microspheres of Antimalarial Drug
Автор:Suresh Sahu and Alpana Ram Год: 2014 Издание:LAP Lambert Academic Publishing Страниц: 112 ISBN: 9783659448157 Malaria is one of the major public health problems in the developing countries. Numbers of drugs are available for the treatment of malaria but chloroquine diphosphate still remains a drug of choice. The aim of this study is to develop and characterize a suitable drug delivery system of antimalarial drug for prophylactic use. A depot system for controlled release of antimalarial drug was prepared. Drug loaded heat cross-linked gelatin microspheres were prepared by single emulsion thermal gelation technique. These were characterised by optical microscopy, scanning electron microscopy (SEM), percentage yield (63.20% to 86.13%), drug content (22.95% to 28.02%), encapsulation efficiency (41.46% to 68.26%, differential scanning calorimetry (DSC) and in vitro studies. Size of the microspheres as observed by optical microscopy were 44.06±6.98 µm to 54.70±8.19 µm, DSC pattern showed absence of drug and polymer interaction. The gelatin microspheres were below 60 µm and spherical in shape as...
