Автор:Adel S. El-Azab and Alaa A.-M. Abdel-Aziz Год: 2014 Издание:LAP Lambert Academic Publishing Страниц: 152 ISBN: 9783659555466 Click Chemistry ‘CC’ are Cu(I) catalyzed 1,3-dipolar [3+2] cycloaddition between azides and alkynes [CuAAC]. The versatility of CuAAC or ‘click reaction’ seem endless with the discovery and invention of new chemical transformations which meet ‘click’ status, the future looks bright for CC. Recently, Click chemistry has received considerable attention as powerful modular synthesis approach, which has found numerous applications in many areas of modern organic chemistry, drug discovery, radiopharmaceutical sciences and material science. The great success of CC encouraged researchers to develop alternative “spring-loaded” chemical reactions for use in different fields of chemistry. Initially, CuAAC was the only click reaction. In recent years, metal-free [3+2] cycloaddition reactions, Diels–Alder reactions, and thiol-alkene radical addition reactions have come to the fore as click reactions because of their simple synthetic procedures and high yields. Also, these metal-free...
