Biological activities of 1,3,4-oxadiazole Derivatives
Автор:Arvind kumar singh and R. Parthasarthy Год: 2012 Издание:LAP Lambert Academic Publishing Страниц: 56 ISBN: 9783659112751 1, 3, 4-Oxadiazole are heterocyclic compounds containing one oxygen & two nitrogen atom in a five membered ring. 1,3,4-oxadiazole derivatives have to placed a major role in the pharmaceutical chemistry .The number of so many synthetic compounds with oxadiazole nucleus used for antibacterial ,antifungal , analgesic and anti-inflammatory activities .Derivatives of 1,3,4-oxadiazole with suitable substitution at 2,5 – position have been already reported to possible biological activities . 1,3,4-oxadiazole derivatives act as anticonvulsant & diuretics. These observation and our interest in the pharmaceutical chemistry of heterocyclic compounds promoted us,we have synthesized different derivatives of,1,3,4-oxadiazole with different substituent at 2&5-position . These derivatives have been also screened for their anti-inflammatory activity.Mostly five membered aromatic system having three heteroatom’s at symmetrical position have been studied because of their physiological...
