Anti-cancer activities of some bacterial polysaccharides derivatives
Автор:Azza El Amir Год: 2014 Издание:LAP Lambert Academic Publishing Страниц: 144 ISBN: 9783659637919 BSL could be a promising anti-initiation agent in vitro through inhibition of CYP 1A mediated carcinogen metabolism and induction of GST activity as well as GSH level. BSL also possesses anti-inflammatory activity through its capacity to enhance macrophage proliferation rate and its ability to inhibit stimulated NO, TNF-? and COX-2 levels. Besides preventing tumor promotion, BSL showed inhibitory activity toward DNA fragmentation and cytotoxic property against Hep-G2 tumor cell line as anti-progression properties. In vivo administration of BSL before and after DEN induction showed inhibitory activity toward HDAC and lipid peroxidation which induced by DEN. Also, BSL modulates GST-P expression which upregulated with DEN injection. It resulted in a significant increase in GST activity and GSH level. It downregulates TNF-? level and induced apoptosis. Anti-progression properties of BSL represented by its inhibitory activities to DNA fragmentation and VEGF where PDGF level was unaffected....
