Автор:Gaurav Agrawal Год: 2012 Издание:LAP Lambert Academic Publishing Страниц: 112 ISBN: 9783659236884 Life is a never-ending battle against infectious micro-organisms. Most of the time, this struggle rages below the radar screen of our awareness as our body’s many innate defense mechanisms prevail keeping us in a state of relative health. However,occasionally these defenses are breached, typically by pathogens that have evolved specialized strategies to subvert or avoid rejection by hard-wired innate immune mechanisms. Such infections require more sophisticated and flexible defense strategies afforded by lymphocytes that make up our adaptive immune system.Adaptive immune responses are characterized by the capacity to recognize and remember pathogen-specific antigens.Although these general principles are now well-established, many of the all important fine details are still incompletely understood. What are the rules that govern the priming of CD4 and CD8 T cells by antigen-presenting cells in vivo? What are the signals for Bcell activation and differentiation? Once an antigenic...
