Solubility enhanced itraconazole Anti-fungal gel formulation
Автор:Mohd Abdul Hadi,Avanapu Srinivasa Rao and Jeevan Prakash Год: 2013 Издание:LAP Lambert Academic Publishing Страниц: 124 ISBN: 9783659412486 All our body organs are not like the brain, heart or the lungs. Something is also there which we wear on the otside. Skin is our largest organ—adults carry some 8 pounds (3.6 kilograms) and 22 square feet (2 square meters) of it. This fleshy covering does a lot more than make us look presentable. Its ability to maintain applied preparation intact for a prolonged time have resulted in its increased use as a route of administration whether for local, regional or systemic effects. Gels are better percutaneously absorbed than cream or ointment bases. Itraconazole is a broad spectrum triazole anti-fungal used to contol the prophylaxis of fungal infections in immunocompromised patients. The major drawback of this drug is that it is practically insoluble in water. Solid dispersions have been widely reported as an effective method for enhancing the solubility and dissolution rate. Hence, in the present research work we have successfully developed solid dispersion incorporated gels of...
