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Автор: Sana Shamim
Год: 2012
Издание:
LAP Lambert Academic Publishing
Страниц: 260
ISBN: 9783848442164
The book deals with the metal complexes of Azithromycin, a macrolide and gemifloxacin, fourth generation fluoroquinolone antibacterial which were synthesized characterized and their antimicrobial activities against various Gram negatives, Gram positives and antifungal species were analyzed. Interaction of gemifloxacin with co-administered drugs was also studied and for this purpose their methods on RP-HPLC were developed for the first time. To support these findings gemifloxacin derivatives were synthesized and characterized by physicochemical and spectroscopic methods with above mentioned interacting drugs. Gemifloxacin analogues were synthesized with different aromatic and aliphatic amines, amides, carboxylic acid, and phenols. In this work, we focused on C-3 and C-7 positions of gemifloxacin. The target derivatives were characterized by FT-IR, 1HNMR and mass spectrometry. Antimicrobial and antifungal activity of these newly synthesized analogues was also carried out. Enzymatic...
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