Calcium Channel Blockers Against MPTP Induced Parkinson’s In Rats
Автор:Puneet Kumar,Ankita Mehta and Rahul Deshmukh Год: 2014 Издание:LAP Lambert Academic Publishing Страниц: 84 ISBN: 9783659536762 The present study has been designed to investigate the protective effect of calcium channel blockers against MPTP - induced Parkinson’s disease-like symptoms in rats. The novel protocol showed that repeated bilateral infusion of MPTP into the SNpc by stereotactic surgery caused degeneration of nigrostriatal dopaminergic neurons. Body weight and behavioral parameters (locomotor, rotarod and activity on narrow beam walk) were assessed on 14th, 21st and 28th day post-MPTP administration. Malondialdehyde, nitrite concentration, superoxide dismutase, catalase levels and Cytokines level (TNF-? and IL-1?) were measured on the 28th day. Administration of MPTP significantly impaired behavioral and biochemical parameters, suggesting significant mitochondrial dysfunction as compared to sham control rats. Further, increased level of TNF-? and IL-1? conferred neuroinflammation after MPTP administration in brain. Post treatment with cilnidipine dual L- and N- type and verapamil L-type for 14 days...
