Vaccine therapy of colorectal cancer patients with tumor antigens
Автор:Gustav Ullenhag Год: 2010 Издание:LAP Lambert Academic Publishing Страниц: 144 ISBN: 9783843356183 For the first time two tumor-associated antigens were evaluated as adjuvant therapy in combination with granulocyte colony stimulating factor (GM-CSF) for patients with colorectal cancer. The ?rst study involved immunization with the protein, carcinoembryonic antigen (CEA) during one year. This vaccination regimen induced a strong immunoglobulin 1 (IgG1) and IgG4 and a moderate IgG2 response against CEA. The humoral as well as the T cell responses were protracted up to 36 months. The dose of CEA had no or modest effect on these responses. The anti-CEA IgG titers related signi?cantly to survival. Functional HLA-DR epitopes of CEA could be de?ned which may serve as components of a vaccination strategy. The other vaccine strategy consisted of the epithelial cell adhesion molecule (Ep-Cam) expressed as a transgene in a viral vector, ALVAC. Patients were immunized over 6 weeks. No anti-Ep-Cam speci?c humoral response was induced, but eventually Ep-Cam speci?c type 1...
