Oxidative Stress and Wound Healing in Type 2 Diabetics with Foot Ulcer
Автор:Elizabeth Bolajoko and Kensese Mossanda Год: 2014 Издание:LAP Lambert Academic Publishing Страниц: 244 ISBN: 9783838328096 Lower-limb infections are major causes of morbidity and mortality in diabetic patients. Oxidative stress (OS) has been implicated in the pathogenesis of diabetes mellitus and its complications including diabetic foot ulcer. Persistent hyperglycaemia leads to an increased production of reactive oxygen species (ROS) through glucose auto-oxidation, sorbitol pathway and protein glycation. This study investigated the effects of selenium, Vitamins C & E supplementations on OS indices: 4-hydoxy-2?-nonenal (4-HNE), lipid peroxides (LPO) and 8–hydroxy–2?–deoxyguanosine (8–OHdG) as well as antioxidant defence system: Superoxide dismutase (SOD), glutathione peroxidase (GPx) and total antioxidant status (TAS)on wound healing in diabetic ulcers in both experimental and clinical models. Data before supplementation revealed higher levels of 4-HNE, LPO and 8-OHdG in diabetic groups with or without ulcer compared with the non-diabetic groups. The diabetic ulcer groups exhibited greater increase in...
