Фармакология, рецептура

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Chemical and Biological Evaluation of Spilanthes paniculata Linn.

Автор: Hemayet Hossain,A.F.M. Shahid -Ud-Daula and Kamrul Hasan
Год: 2012
Издание: LAP Lambert Academic Publishing
Страниц: 104
ISBN: 9783659114052
The crude ethanolic extract of the leaves of Spilanthes paniculata (Linn.) was evaluated for analgesic and antioxidant activities in different methods. At the dose 500 mg/kg body weight, the extract showed significant analgesic activity in acetic acid induced writhing in mice showing 37.61% inhibition (P>0.001) comparable to that produced by Diclofenac Na (45.02%) used as standard drug. Four complementary test systems, namely DPPH free radical scavenging, reducing power, Fe++ ion chelating ability, total phenolic compounds were used for the analysis. In DPPH free radical scavenging test, IC50 value for ethanolic crude extract was found fairly significant (8.59 ± 0.082 ?g/ml) while compared to the IC50 value of the reference standards ascorbic acid and BHA (1.93 ± 0.027 & 4.10 ± 0.035 ?g/ml) respectively. In reducing power test the maximum absorbance for ethanolic crude extract was found to 2.152 ± 0.016 at 100 ?g/ml while compared to 2.811 ± 0.013 and 2.031 ± 0.019 for standard...
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