Application of Proteomics Tools in Breast Cancer Research
Автор:Priyanka Maurya and Niraj Kumar Год: 2012 Издание:LAP Lambert Academic Publishing Страниц: 120 ISBN: 9783848410019 Breast cancer is the second leading cause of cancer deaths and is the most common cancer among women. Although a number of biomarkers are being used in clinical practice, significant number cases for breast cancers are detected late and difficult to treat. Therefore, new biomarkers are in need to improve diagnosis and the therapeutics for breast cancer. The emergence of proteomics technologies has facilitated researcher comprehensive differential expression analyses of proteins in healthy and cancer individuals. The most commonly used proteomic techniques in breast cancer research are 2D-PAGE, SELDI-ToF MS, Protein Arrays, ICAT, iTRAQ and SILAC. Recent advancement in proteomics has also enabled to study the intracellular signalling pathways that may underlie the development of breast cancer. Thus, proteomics could play significant roles in identification of novel biomarkers and/or drug targets to improve existing prognosis and diagnosis of breast cancer. This book covers a selection...
