Anti-tumour Properties of Iraqi Propolis: in vitro and in vivo
Автор:Ghassan Sulaiman,Khulood Al Sammarae and Ali Ad'hiah Год: 2012 Издание:LAP Lambert Academic Publishing Страниц: 232 ISBN: 9783846554555 Healing properties of propolis are known in folk medicine from antiquity; however, recently, the interest in propolis as a potential natural product is increasing because of its broad spectrum of biological properties. It is an anti-flammatory agent, an immunostimulant, anti-oxidant, anti-microbial, and it is also an anti-tumour and a carcinostatic agent. This study was undertaken to characterize the chemical compounds, and antioxidant and anti-tumour potentials of propolis samples collected from five different geographical locations in Iraq using in vitro and in vivo studies. Thirty-eight different compounds were identified, and clerodane diterpenoids were identified for first time in temperate zone. All propolis samples exhibited strong free radical scavenging activity. The in vitro evaluations by growth inhibition, clonogenicity and flow cytometric assays showed that propolis has cytotoxic effects on two human cell lines. The in vivo potentials were also recorded on the growth of...
