История химии. Общие работы по химии

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A Novel Enantioselective Synthesis of Spiro-Oxindoles

Автор: Sesha Sridevi Alluri,Chih-Hung Wang and Michael Bertucci
Год: 2010
Издание: LAP Lambert Academic Publishing
Страниц: 76
ISBN: 9783838355085
Spiro-Pyrrolidine-Oxindole is a recurring structural element that has been identified in numerous alkaloids and pharmacologically active compounds. These spiro-fused ring systems embody stereochemical and structural complexities that continue to challenge the synthetic chemist. This book describes a novel enantioselective synthesis of the spiro-pyrrolidine-oxindole ring system in a highly convergent manner.The key steps for the synthesis involve 1,3-dipolar cycloaddition reaction to form the pyrrolidine ring system and radical reaction for the formation of quarternary center. The present synthesis is efficient and would allow preparation of a library of compounds for biological screening.
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